Edarbyclor contains a combination of azilsartan and chlorthalidone. Azilsartan is an angiotensin II receptor blocker. Chlorthalidone is a thiazide diuretic that helps prevent your body from absorbing too much salt, which can cause fluid retention. Edarbyclor is used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack. Edarbyclor contains a combination of azilsartan and chlorthalidone. Azilsartan is an angiotensin II receptor blocker. Chlorthalidone is a thiazide diuretic that helps prevent your body from absorbing too much salt, which can cause fluid retention. Edarbyclor is used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.